Current research on UV-induced DNA damage and its role in promoting the development of skin malignancies
10.3969/j.issn.1674-8115.2025.02.012
- VernacularTitle:紫外线诱导的DNA损伤促进皮肤恶性肿瘤发生的研究现状
- Author:
Boyuan ZHANG
1
;
Zhirong YAO
1
Author Information
1. 上海交通大学医学院附属新华医院皮肤病中心,上海 200092;上海交通大学医学院附属新华医院皮肤科,上海 200092;上海交通大学医学院皮肤病研究所,上海 200092
- Publication Type:Journal Article
- Keywords:
skin malignant tumor;
ultraviolet rays;
DNA damage
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2025;45(2):228-232
- CountryChina
- Language:Chinese
-
Abstract:
Skin malignancies include non-melanoma skin cancers and melanoma,with high incidence rates that pose a significant burden on public health and healthcare systems.Research in this area is crucial.Ultraviolet radiation(UV)is recognized as the primary risk factor for skin malignancies,with its main carcinogenic mechanism involving UV-induced DNA damage,which leads to the accumulation of mutations in key oncogenes and tumor suppressor genes.This accumulation promotes malignant transformation of related cells,ultimately resulting in the formation of malignant tumors.Understanding the specific processes through which UV-induced DNA damage contributes to the development of skin malignancies is crucial for advancing related research.Therefore,this paper focuses on the mechanisms of UV-induced DNA damage,the repair mechanisms for UV-induced DNA damage,and the relationship between UV-induced DNA damage and the occurrence of the three major types of skin malignancies.
