Prospective Association Between Chinese Visceral Adiposity Index and Risk of Stroke Incidence in Middle-aged and Elderly Chinese Population
10.12290/xhyxzz.2024-0540
- VernacularTitle:中国人内脏脂肪指数与中老年人群脑卒中发病风险的前瞻性关联
- Author:
Miaomiao SHAO
1
;
Zhengzhen CHEN
1
Author Information
1. 温州医科大学仁济学院,浙江 温州 325035
- Publication Type:Journal Article
- Keywords:
Chinese visceral adiposity index;
stroke;
middle-aged and elderly;
prospective association;
disease prevention
- From:
Medical Journal of Peking Union Medical College Hospital
2025;16(4):922-929
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between the Chinese visceral adiposity index(CVAI)and the risk of stroke incidence in middle-aged and older adults(≥45 years)using data from the China Health and Retirement Longitudinal Study(CHARLS).Methods Data from the 2015,2018,and 2020 CHARLS surveys were analyzed,focusing on middle-aged and older adults.The primary outcome was the occur-rence of new stroke events(including both hemorrhagic and ischemic strokes)during the follow-up period.Co-variates included general demographic characteristics,lifestyle factors,health status,and blood biomarkers.Cox proportional hazards regression models were used to explore the dose-response relationship between CVAI and stroke risk.Results A total of 11 432 middle-aged and older adults were included,with a mean age of 60.24±9.56 years.Among them,6157(53.86%)were women and 5275(46.14%)were men.Over a me-dian follow-up period of 5 years,905 individuals(7.92%,905/11 432)experienced a stroke.After adjusting for demographic and lifestyle covariates,each interquartile range(IQR)increase in CVAI was associated with a 28%higher risk of stroke(HR=1.28,95%CI:1.20-1.36).Compared to the first quartile(Q1),the third(Q3:HR=1.60,95%CI:1.30-1.97)and fourth quartiles(Q4:HR=2.02,95%CI:1.65-2.47)were significantly associated with an increased risk of stroke.Interaction analysis revealed a significant interaction be-tween CVAI and gender(Pfor interaction＜0.001).Restricted cubic spline analysis demonstrated a non-linear rela-tionship between CVAI and stroke risk(Pnonlinear=0.005).Conclusions Higher CVAI levels are associated with an increased risk of stroke.CVAI serves as an effective biomarker for identifying individuals at high risk of stroke and can inform primary stroke prevention strategies.
