Precision Theranostics in Nuclear Medicine Targeting Gastrin-Releasing Peptide Receptor
10.12290/xhyxzz.2025-0479
- VernacularTitle:靶向胃泌素释放肽受体的核医学精准诊疗
- Author:
Rongxi WANG
1
;
Zhaohui ZHU
;
Xiaoyuan CHEN
Author Information
1. 中国医学科学院北京协和医院核医学科,北京 100730
- Publication Type:Journal Article
- Keywords:
gastrin-releasing peptide receptor;
radiopharmaceutical;
diagnosis;
therapy
- From:
Medical Journal of Peking Union Medical College Hospital
2025;16(4):812-816
- CountryChina
- Language:Chinese
-
Abstract:
The gastrin-releasing peptide receptor(GRPR)is highly expressed in various malignant tumors(e.g.,glioblastoma,prostate cancer,and breast cancer)and has emerged as an important molecular target for precision cancer diagnosis and therapy.In recent years,the combined application of radionuclide-la-beled GRPR ligands with positron emission tomography/computed tomography(PET/CT)has achieved ground-breaking progress in noninvasive diagnosis,accurate staging,and therapeutic monitoring of GRPR-positive tumors.Meanwhile,GRPR-targeted radionuclide therapeutics have demonstrated significant therapeutic potential and promising clinical applications in trials.This GRPR-based theranostic strategy pioneers a novel ap-proach for precision medicine in GRPR-overexpressing tumors.
