Clinical pathology characteristics and prognosis of 18 patients with primary thyroid lymphoma
10.3760/cma.j.cn113855-20250113-00025
- VernacularTitle:18例原发性甲状腺淋巴瘤的临床病理特点及预后分析
- Author:
Lingyi DONG
1
;
Han JIANG
;
Dongyu BAI
;
Fuxing ZHANG
Author Information
1. 厦门大学附属第一医院普外科，厦门 361000
- Publication Type:Journal Article
- Keywords:
Thyroid neoplasms;
Lymphoma;
Thyroiditis,autoimmune;
Pathology,Clinical
- From:
Chinese Journal of General Surgery
2025;40(10):796-801
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the clinical characteristics of primary thyroid lymphoma (PTL) and the prognoses.Methods:A retrospective analysis was performed on the clinical data, prognosis and influencing factors of 18 PTL patients at the First Affiliated Hospital of Xiamen University from Oct 2012 to Aug 2021.Results:There were 12 females and 6 males, average age of (60±11.5)years. Fifteen patients were complicated with hashimoto's thyroiditis (HT). Seventeen patients received treatments including surgery, chemotherapy, radiotherapy, and targeted therapy. Median follow-up time was 35.8 months. Four cases suffered from recurrence and progression, and 3 cases died. The 3-year overall survival rate(OS) was 94%, and the 5-year OS rate was 83%. The 3-year progression-free survival(PFS)rate was 89%, and the 5-year PFS rate was 79%. The OS rate and PFS rate of patients with HT were higher than those of patients without ( P<0.05). The 5-year OS rates were 100% vs.33% ( χ2=7.681, P=0.006), and the 3-year PFS rates were 93% vs. 67% respectively( χ2=5.368, P=0.021). The OS and PFS of patients who had undergone surgical treatment were higher than those of patients without ( P<0.01). The 5-year OS rates were 100% vs.40% ( χ2=8.579, P=0.003), and the 5-year PFS rates were 100% vs.30% ( χ2=12.267, P<0.001).The PFS rate of patients aged ≤60 years was higher than that of patients aged >60 years, and the difference was statistically significant ( P<0.05). The 5-year PFS rates were 100% vs. 56% ( χ2=4.906, P=0.027). Conclusions:PTL shows a female predominance and tends to occur at a relatively advanced age. The overall prognosis of PTL patients is favorable after multidisciplinary treatment.Patients with HT or who have undergone surgical treatment tend to have relatively longer survival periods.
