Clinical pathology characteristics of thyroid cancer in children, adolescents and young adults
10.3760/cma.j.cn113855-20250117-00038
- VernacularTitle:儿童、青少年及青年甲状腺癌的临床病理特征分析
- Author:
Meiling HUANG
1
;
Changjiao YAN
1
;
Ting WANG
1
Author Information
1. 中国人民解放军空军军医大学西京医院甲乳血管外科，西安 710032
- Publication Type:Journal Article
- Keywords:
Thyroid neoplasms;
Child;
Adolescent;
Pathology, clinical
- From:
Chinese Journal of General Surgery
2025;40(10):789-795
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the clinical characteristics of pediatric, adolescent, and young adult thyroid cancer patients treated from Jan 2012 to Jul 2022.Methods:A retrospective analysis was conducted on the pathological and ultrasound features, treatment methods, and survival outcomes of thyroid cancer in three groups: the pediatric group (0-14 years), the adolescent group (15-19 years), and the young adult group (20-39 years).Results:The number of pediatric and adolescent patients showed a relatively stable growth trend, while the proportion of microcarcinomas was significantly higher in the young adult group. Significant differences were observed among the groups in T stage, N stage, M stage, extrathyroidal extension, local invasion, lymph node metastasis, number of metastatic lymph nodes, and tumor hypoechogenicity (all P<0.05). Preoperative thyroid function tests revealed differences in free triiodothyronine (FT3), triiodothyronine (T3), and thyroglobulin (Tg) levels (all P<0.05). All patients underwent thyroidectomy or lobectomy, with significant differences in contralateral neck lymph node dissection rates ( χ2=30.089, P<0.001). Postoperative lymphatic leakage incidence varied ( χ2=8.376, P=0.015), and the proportion of patients receiving postoperative 131I therapy differed significantly ( P<0.001). Significant differences were observed in postoperative recurrence and secondary surgery rates. Multivariate analysis identified FT3, T3, and pathological type as risk factors for recurrence. The three groups showed significant differences in postoperative calcium supplementation upon discharge, with insufficient attention given to bone health and cardiovascular risks. Conclusion:Pediatric, adolescent, and young adult thyroid cancer patients exhibit differences in incidence and pathological characteristics, but no significant difference was found in overall survival.
