Risk factors predicting postoperative permanent hypoparathyroidism in patients undergoing total thyroidectomy for thyroid cancer
10.3760/cma.j.cn113855-20231201-00382
- VernacularTitle:甲状腺癌全切除术后永久性甲状旁腺功能减退的影响因素分析
- Author:
Tianhao ZHANG
1
;
Zhiwei HAO
1
;
Jie AN
1
;
Jin LI
1
;
Jinhang LI
1
;
Zhanwu JIANG
1
Author Information
1. 河北省保定市第一中心医院普通外二科, 保定 071000
- Publication Type:Journal Article
- Keywords:
Thyroid neoplasms;
Hypoparathyroidism;
Thyroidectomy;
Risk factors
- From:
Chinese Journal of General Surgery
2025;40(10):784-788
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate risk factors for permanent hypoparathyroidism (PHPP) after total thyroidectomy in patients with differentiated thyroid carcinoma (DTC).Methods:The clinical data of 316 DTC patients who underwent total thyroidectomy at our hospital from Jan 2020 to Jan 2023 were retrospectively analyzed. Patients were divided into normal parathyroid function group (284 cases) and hypoparathyroidism group (32 cases) according to whether parathyroid function was decreased. The clinical examination, intraoperative conditions and postoperative pathological data of the two groups were statistically analyzed.Results:Logistic regression analysis showed that: serum calcium on the first postoperative day ( OR=0.163, P<0.05), parathyroid hormon (PTH) on the first postoperative day ( OR=0.958, P<0.05), bilateral lymph node dissection ( OR=3.138, P<0.05), accidental resection of parathyroid (PG) ( OR=2.614, P<0.05), posterior capsule tumor invasion ( OR=3.336, P<0.05) and multiple cancer foci ( OR=2.664, P<0.05) were independent risk factors for PHPP after total thyroidectomy. Conclusion:Postoperative day 1 serum calcium, postoperative day 1 PTH, bilateral lymph node dissection, accidental resection of PG, posterior capsule invasion and multiple cancer foci are independent risk factors for PHPP after total thyroidectomy.
