Study on the Serum Expression Levels of Zonulin and Claudin-5 and Their Correlation with the Severity of Clinical Psychiatric Symptoms in Patients with Schizophrenia
10.3969/j.issn.1671-7414.2025.01.017
- VernacularTitle:精神分裂症患者血清Zonulin和Claudin-5表达水平与临床精神症状严重程度的相关性研究
- Author:
Chunming HUANG
1
;
Xin PAN
1
;
Xihua ZHU
1
Author Information
1. 黑龙江省第三医院精神科重症监护病房,黑龙江北安 164000
- Publication Type:Journal Article
- Keywords:
schizophrenia;
zonulin;
claudin-5;
mental symptoms
- From:
Journal of Modern Laboratory Medicine
2025;40(1):90-93,104
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate serum levels of Zonulin and Claudin-5 in patients with schizophrenia (SZ) and their relationship with the severity of psychiatric symptoms. Methods 98 patients with SZ treated in the Third Hospital of Heilongjiang Province form April 2019 to April 2022 were selected as the SZ group,and 50 healthy people who underwent physical examination were selected as the control group. Enzyme-linked immunosorbent assay was used to detect serum levels of Zonulin and Claudin-5. Pearson correlation analysis was used to analyze the relationship between serum Zonulin and Claudin-5 levels and clinical parameters in patients with SZ. Logistic regression was used to analyze the risk factors for SZ. Receiver operating characteristic curve was used to analyze the diagnostic value of serum Zonulin and Claudin-5 for SZ. Results The serum level of Zonulin in SZ group(7.91±0.52μg/L)was higher than that in control group (2.31±0.24μg/L),and the serum level of Claudin-5(12.17±2.34ng/L)was lower than that in control group(26.78±5.15 ng/L),the differences were statistically significant (t=72.235,23.740,all P<0.05).The total scores of Positive and Negative Symptom Scale (PANSS) score,positive and negative symptom scores,general psychiatric symptom scores was positively correlated with serum Zonulin (r=0.660～0.720,all P<0.05),and negatively correlated with serum Claudin-5 (r=-0.720～-0.622,all P<0.05).Serum Zonulin,PANSS total score,positive symptom score and general psychopathology symptom score were risk factors for SZ,and Claudin-5 was a protective factor (all P<0.05).The AUC(95％CI)of serum Zonulin and Claudin-5 combined for SZ diagnosis was 0.932(0.891～0.959),which was higher than that of serum Zonulin and Claudin-5 single diagnosis were 0.814(0.779～0.847),0.846(0.811～0.882),respectively,and the differences were statistically significant (Z=5.145,4.210,all P<0.05). Conclusion The increase in serum Zonulin levels and the decrease in Claudin-5 levels in SZ patients are related to the severity of their mental symptoms. The combined detection of serum Zonulin and Claudin-5 has high diagnostic value for SZ.
