Risk factors for peripheral nerve infiltration in intrahepatic cholangiocarcinoma and prognostic significance
10.3760/cma.j.cn113855-20240829-00560
- VernacularTitle:肝内胆管癌周围神经浸润危险因素分析及对预后的影响
- Author:
Ting WANG
1
;
Jie CHEN
1
;
Junfen HU
1
;
Jing HUANG
1
Author Information
1. 宁波大学附属李惠利医院肝胆胰外科，宁波 315000
- Publication Type:Journal Article
- Keywords:
Liver neoplasms;
Pathology,surgical;
Cholangiocarcinoma;
Peripheral nerve infiltration;
Risk factors
- From:
Chinese Journal of General Surgery
2025;40(5):366-369
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the risk factors of intrahepatic cholangiocarcinoma (ICC) with peripheral nerve infiltration (PNI) and the effect of PNI on prognosis.Methods:The clinicopathological and survival data of 153 patients with ICC who underwent radical resection at the Department of Hepatopancreatobiliary Surgery, the Affiliated Lihuili Hospital of Ningbo University from Jan 2012 to Feb 2024 were retrospectively analyzed.Results:There were 144 patients enrolled, including 67 patients in the PNI positive group; 77 patients in the PNI negative group. Multivariate Logistic analysis showed that vascular tumor thrombus and intrahepatic bile duct stones were independent risk factors for ICC with PNI (all P<0.05). The overall recurrence rate of PNI positive patients (71.64 %) was significantly higher than that of PNI negative patients (49.35 %), with statistically significant differences between the two groups ( P<0.05). The median recurrence-free survival time of PNI positive patients was 12 months compared to 32 months in PNI negative patients, with statistically significant differences between the two groups ( P<0.05). The median survival time of PNI positive patients was 15 months vs. 42 months in PNI negative patients with statistically significant differences between the two groups ( P<0.001). Conclusion:Vascular tumor thrombus and intrahepatic bile duct stones are independent risk factors for ICC with PNI, and ICC patients with negative PNI have a less gloomy prognosis.
