Two cases of microsatellite stable locally advanced gastric cancer achieving pathological complete response by laparoscopic total gastrectomy after immunotherapy combined with neoadjuvant chemotherapy
10.3760/cma.j.cn113855-20240716-00468
- VernacularTitle:免疫治疗联合新辅助化疗治疗微卫星稳定局部进展期胃癌病理完全缓解2例分析
- Author:
Yuan FANG
1
;
Chao HAN
;
Shijun XIANG
;
Renchao ZHANG
;
Gang CEN
;
Qingguo WANG
;
Lin YUAN
;
Yan XING
;
Zhengjun QIU
;
Chen HUANG
Author Information
1. 上海交通大学医学院附属第一人民医院普外临床医学中心胃肠外科，上海 200080
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Microsatellite stable;
Immunotherapy;
Chemotherapy,adjuvant;
Pathological complete response
- From:
Chinese Journal of General Surgery
2025;40(4):268-273
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate immunotherapy combined with neoadjuvant chemotherapy before radical total gastrectomy in microsatellite stable locally advanced gastric cancer in two cases.Methods:Two male patients with clinical stage cT3N 1M0 and microsatellite-stable locally advanced gastric cancer were treated with neoadjuvant chemotherapy with PD-1 inhibitor (Nivolumab) combined with SOX (Oxaliplatin+S-1) for 4 cycles before surgery. Standard laparoscopic assisted total gastrectomy with D 2 lymphadenectomy was performed on Feb 2023 and Oct 2023 respectively after the neoadjuvant treatment. Pathological tumor regression grade(TRG) was observed to assess the degree of tumor regression, and follow-up was conducted to monitor tumor markers and abdominal enhanced CT to detect recurrence. Results:Two patients achieved pathological complete response(TRG0). They were followed up until May 2024 and no recurrence was observed.Conclusion:Preoperative combination of chemotherapy and immunotherapy may provide survival benefit for microsatellite stable locally advanced gastric cancer patients.
