High-risk factors for early postoperative recurrence in patients with colorectal cancer liver metastasis
10.3760/cma.j.cn113855-20240925-00602
- VernacularTitle:结直肠癌肝转移患者术后早期复发的高危因素分析
- Author:
Leibin SHEN
1
;
Mian YANG
1
;
Liangbin JIN
1
;
Tao PENG
1
;
Bo ZHOU
1
;
Jiaze SUN
1
;
Jiazi YU
1
Author Information
1. 宁波大学附属李惠利医院结肠肛肠外科，宁波 315020
- Publication Type:Journal Article
- Keywords:
Colonic neoplasms;
Rectal neoplasms;
Liver metastasis;
Postoperative recurrence;
Risk factors
- From:
Chinese Journal of General Surgery
2025;40(3):207-212
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the high-risk factors for early postoperative recurrence in patients with colorectal cancer liver metastasis (CRLM).Methods:The clinical data of 156 CRLM patients who underwent hepatic metastasectomy at the Li Huili Hospital, Ningbo University from Jan 2015 to Dec 2021 was retrospectively analyzed.Results:Among 156 patients, the postoperative recurrence rate was 55.8% (87/156).There were significant differences ( P<0.05) in the primary tumor site, T stage, TBS score, preoperative concentrations of CEA, CA199 and CA125, the maximum diameter of metastatic tumors and the number of metastatic tumors between the group with recurrence in one year and the group without recurrence in one year. Multivariate analysis showed that preoperative CA125 concentration ( OR=1.021, P=0.020), CEA concentration ( OR=1.044, P=0.018), and tumor burden score ( OR=3.067, P=0.011) were high risk factors influencing early recurrence ( P<0.05). In the low TBS score group(≤4), among the 49 patients who underwent simultaneous resection, 13 suffered from recurrence within 1 year, with a recurrence rate of 26.5%. Meanwhile, among the 29 patients who underwent staged resection, 17 suffered from recurrence within 1 year, with a recurrence rate of 58.6% ( P<0.05). In the high TBS score group(>4), among the 51 patients who underwent simultaneous resection, 37 suffered from recurrence within 1 year, with a recurrence rate of 72.5%, while in the 27 patients who underwent staged resection, 20 suffered from recurrence within 1 year, with a recurrence rate of 74.1% ( P>0.05). Conclusions:Preoperative TBS score, preoperative CA125 concentration, and CEA concentration are high-risk factors for postoperative recurrence in patients with colorectal liver metastases, simultaneous resection in patients with a low TBS score can reduce the risk of recurrence within 1 year after surgery.
