Effects of physiological ischemia training in inhibiting ventricular remodeling and ventricular arrhythmia in patients after myocardial infarction
10.3969/j.issn.1001-1242.2025.02.009
- VernacularTitle:生理性缺血训练抑制心肌梗死患者心室重构及室性心律失常的作用
- Author:
Weihai CHEN
1
;
Linquan WANG
1
;
Renlin YIN
1
Author Information
1. 苏州大学附属苏州九院,江苏省苏州市,215299
- Publication Type:Journal Article
- Keywords:
physiological ischemic training;
acute myocardial infarction;
early ventricular remodeling;
ventricu-lar arrhythmias;
revascularization
- From:
Chinese Journal of Rehabilitation Medicine
2025;40(2):223-230
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To verify whether physiological ischemia training(PIT)can inhibit ventricular remodeling and re-duce the occurrence of ventricular arrhythmias in the early stage of acute myocardial infarction(AMI).Method:AMI patients with hypotensive or slow heart rate(HR)group were divided into PIT(n=21)and control(n=20)groups randomly,while patients with normal blood pressure(BP)and heart rate were divided into a PIT combined with drug angiotensin-converting enzyme inhibitor and/or β-blocker(AB)group(n=30)and a sole AB group(n=30).After 3 months of intervention,indicators including renin-angiotensin-aldosterone system(RASS)activity,ventricular remodeling,cardiac function,vascular neovascularization,and ventricular arrhythmias were compared among the groups.Result:After 3 months of intervention,RASS activity,ventricular remodeling,left ventricular ejection frac-tion(LVEF)and QT dispersion(QTd)were significantly improved in PIT,PIT+AB and AB groups(P＜0.05),with the PIT+AB group showing more significant improvements than the AB(P＜0.05).Following the 3-month intervention,the levels of vascular endothelial growth factor(VEGF)and nitric oxide(NO)in the circulation significantly increased in the PIT and PIT+AB groups(P＜0.05).The Lown's classification of all four groups was significantly reduced after 3-month intervention(P＜0.05),with the most significant reduction in the PIT+AB group(P＜0.05).During PIT,diastolic blood pressure(DBP)increased to some extent,while there were no significant effects on systolic blood pressure(SBP)and heart rate.Conclusion:PIT can effectively inhibit early ventricular remodeling in post-myocardial infarction patients,pro-motes the neogenesis of coronary collateral circulation,and reduce the risk of ventricular arrhythmias after myo-cardial infarction,thereby improving cardiac function to some extent,which can be further benefit patients if PIT combines with ACEIs/ARBs and beta-blockers.
