The effect of anti-reflux sleeve gastrectomy and sleeve gastrectomy on the levels of adipokines and inflammation related cells
10.3760/cma.j.cn113855-20241107-00684
- VernacularTitle:新型抗反流袖状胃切除术的疗效及其对循环脂肪因子与炎症相关细胞水平的影响
- Author:
Xudong HUANG
1
Author Information
1. 新疆维吾尔自治区人民医院微创、疝和腹壁外科 新疆胃食管反流病与减重代谢外科临床医学研究中心 新疆维吾尔自治区普外微创研究所，乌鲁木齐 830002
- Publication Type:Journal Article
- Keywords:
Obesity, morbid;
Adipokines;
Gastrectomy;
Gastroesophageal reflux;
Inflammation
- From:
Chinese Journal of General Surgery
2025;40(4):262-267
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of anti-reflux sleeve gastrectomy and sleeve gastrectomy on circulating adipokines and inflammation related cell levels.Method:A retrospective cohort study was conducted to analyze the data of 45 obese patients undergoing laparoscopic sleeve gastrectomy plus fundoplication (LSGFD) and laparoscopic sleeve gastrectomy (LSG) at Xinjiang Uygur Autonomous Region People's Hospital from Apr to Sep 2023. Patients were followed-up for 6-month .Body weight, fasting plasma glucose (FPG), 2-hour postprandial glucose (2-h PG), GERD questionnaire score (GERD-Q), circulating leptin, adiponectin, peripheral white blood cell count (WBC), neutrophils (NE), lymphocytes (LY), and neutrophil-to-lymphocyte ratio (NLR) between two groups of patients before surgery and 6 months after surgery were conducted.Results:The operative times for the LSGFD group and the LSG group were 180 (105-240) minutes and 125 (85-180) minutes, respectively ( Z=-3.358, P<0.01). There were no statistically significant differences in intraoperative blood loss, total hospital stays, postoperative hospital stays, use of robotic assistance, or readmission within 30 days postoperatively (all P>0.05). Six months after LSG, patient's weight, BMI, 2-h PG decreased ( all P<0.05), Six months after LSGFD, patient's circulating leptin, peripheral blood WBC, NE, and NLR levels decreased ( Z=-3.808, -3.173, -3.435, -2.389, -3.173, all P<0.05). Six months after LSG, patient's circulating leptin, peripheral blood WBC, NE, and NLR levels decreased ( Z=-4.292, -3.606, -3.431, -2.220, -3.619, all P<0.05). Conclusion:LSGFD and LSG not only significantly reduce the weight of obese patients but also improve the levels of circulating adipokines and inflammatory status.
