The impact of plasma bile acid level changes following laparoscopic sleeve gastrectomy on the remission of non-alcoholic fatty liver disease in patients with obesity
10.3760/cma.j.cn113855-20241221-00797
- VernacularTitle:腹腔镜胃袖状切除术后血浆胆汁酸水平改变与肥胖患者非酒精性脂肪性肝病缓解效果的研究
- Author:
Chenxu TIAN
1
;
Qiqige WUYUN
1
;
Liang WANG
1
;
Zhehong LI
1
;
Nengwei ZHANG
1
;
Guangzhong XU
1
Author Information
1. 首都医科大学附属北京世纪坛医院肥胖与代谢病中心，北京 100038
- Publication Type:Journal Article
- Keywords:
Obesity, morbid;
Non-alcoholic fatty liver disease;
Gastrectomy;
Bile acids
- From:
Chinese Journal of General Surgery
2025;40(4):257-261
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between changes in total plasma bile acid (TBA) levels and the remission of non-alcoholic fatty liver disease (NAFLD) in patients with obesity after laparoscopic sleeve gastrectomy (LSG).Methods:A retrospective analysis was conducted on clinical data and follow-up information of 20 patients with obesity and NAFLD undergoing LSG in Beijing Shijitan Hospital between Mar to Jun 2022.Results:Postoperative weight loss was significant. Compared to preoperative values, the weight of 20 patients decreased [(115.92±16.13) kg vs. (78.20±7.77) kg, t=15.675, P<0.001]. The BMI also decreased [(40.66±5.18) kg/m2 vs. (27.43±2.22) kg/m2, t=13.230, P<0.001]. The fatty liver index and hepatic steatosis index decreased significantly [(96.34±5.23) vs. (27.96±20.36), t=16.829, P<0.001; (55.15±6.73) vs. (37.55±4.30), t=16.294, P<0.001]. Plasma TBA levels significantly increased [(7.06±2.80) vs. (12.27±3.79) μmol/L, P<0.001]. Indicators related to glucose, lipids, and liver function in patients significantly decreased. Conclusions:LSG can significantly reduce body weight in patients with obesity and NAFLD and improve NAFLD. LSG can increase plasma TBA levels, and the elevation in TBA levels is positively correlated with the degree of NAFLD remission.
