Research Advances on the Molecular Mechanisms of Myxomatous Mitral Valve Degeneration
10.3969/j.issn.1000-3614.2025.07.013
- VernacularTitle:二尖瓣黏液样变性分子机制研究进展
- Author:
Qixin CHEN
1
;
Feng ZHANG
1
;
Wenqing LIANG
1
;
Hong CHEN
1
;
Sufang LI
1
Author Information
1. 北京大学人民医院 心血管内科 急性心肌梗死早期预警和干预北京市重点实验室 北京大学人民医院心血管转化医学研究中心,北京 100044
- Publication Type:Journal Article
- Keywords:
myxomatous mitral valve degeneration;
molecular mechanism;
extracellular matrix remodeling;
review
- From:
Chinese Circulation Journal
2025;40(7):720-724
- CountryChina
- Language:Chinese
-
Abstract:
Myxomatous mitral valve degeneration(MMVD)is one of the important pathogenic factors of primary mitral regurgitation.The pathological manifestations of MMVD include thickening,redundancy,and prolapse of the valve leaflets,which lead to structural and functional abnormalities of the mitral valve,eventually cause mitral regurgitation.The pathogenesis of MMVD involves abnormalities in three main cell types:valvular interstitial cells,endothelial cells,and monocyte-macrophages.Therefore,a deep understanding of the regulatory mechanisms of these cell types in MMVD is crucial for the diagnosis and treatment of MMVD.This article provides a comprehensive review of the normal tissue structure characteristics of the mitral valve,the morphological features of MMVD,and the research progress on the regulatory roles of the aforementioned cell types in MMVD,aiming to provide a scientific basis for early intervention and precise treatment of MMVD.
