Advances in physiological and molecular mechanisms of therapeutic re-lief of type 2 diabetes mellitus by weight loss
10.3969/j.issn.1000-4718.2025.07.018
- VernacularTitle:减重治疗缓解2型糖尿病的生理及分子机制研究进展
- Author:
Danqi QIU
1
;
Jie CHEN
1
;
Hao LIU
1
;
Li LI
1
;
Shuqin CHEN
1
Author Information
1. 宁波大学附属第一医院内分泌科,浙江 宁波 315000
- Publication Type:Journal Article
- Keywords:
weight loss therapy;
type 2 diabetes remission;
twin cycle hypothesis;
brain-gut axis;
adipokines
- From:
Chinese Journal of Pathophysiology
2025;41(7):1407-1413
- CountryChina
- Language:Chinese
-
Abstract:
Type 2 diabetes mellitus(T2DM)has emerged as a significant public health challenge and a con-siderable threat to human well-being due to its chronic nature.Consequently,it cannot be overlooked.In response to this pressing issue,scientific weight loss treatments have demonstrated their effectiveness as a coping strategy.Particularly,for patients in the early stages of the disease with preserved pancreatic islet function and obesity,weight loss treatment has been shown to significantly enhance their glucose tolerance and ameliorate metabolic disorders.Ongoing research has led to a growing body of evidence regarding the mechanisms and clinical data supporting the use of weight loss therapy in miti-gating type 2 diabetes.This paper aims to evaluate the impact of weight loss therapy on the major metabolic organs of the body,such as the liver,pancreas,skeletal muscle,and adipose tissue,and to delve into the physiological and molecular mechanisms involved in the remission of T2DM.
