Application of Mendelian randomization and its derivatives in the study of risk factors for chronic obstructive pulmonary disease
10.16753/j.cnki.1008-2344.2025.03.013
- VernacularTitle:孟德尔随机化及其衍生方法在慢性阻塞性肺疾病影响因素研究中的应用价值
- Author:
Zhijun TIAN
1
;
Ao SHEN
;
Tiantian LI
;
Huixing LI
;
Yudan ZHOU
;
Hong GUO
Author Information
1. 沈阳医学院公共卫生学院,辽宁 沈阳 110034
- Publication Type:Journal Article
- Keywords:
Mendelian randomization;
Mendelian randomization derivative methods;
chronic obstructive pulmonary disease;
influencing factors
- From:
Journal of Shenyang Medical College
2025;27(3):304-309,327
- CountryChina
- Language:Chinese
-
Abstract:
Chronic obstructive pulmonary disease(COPD),as a global health challenge,brings heavy economic and psychological burdens to patients and their families.Accurately identifying the risk factors for COPD and excluding false associations are crucial for understanding its pathogenesis and formulating prevention strategies.Mendelian randomization(MR),as a supplementary method,has shown great potential in reducing the interference of confounding factors,lowering the cost of experimental research,and avoiding experimental ethical issues.This article focuses on MR and its main derivative methods,discusses their basic principles and applicable conditions,and analyzes their application effects and limitations in COPD research in combination with specific cases,enabling MR to be more widely applied in the study of influencing factors of COPD.
