Penyan pill combined with thunder fire moxibustion in patients with sequelae of pelvic inflammatory disease:a randomized controlled trial
10.12173/j.issn.1005-0698.202412060
- VernacularTitle:盆炎丸联合雷火灸治疗盆腔炎性疾病后遗症的随机对照试验
- Author:
Yi HU
1
;
Yanlan YU
1
;
Li TANG
1
Author Information
1. 湖南中医药大学第一附属医院妇科(长沙 410007)
- Publication Type:Journal Article
- Keywords:
Penyan pill;
Thunder fire moxibustion;
Sequelae of pelvic inflammatory disease;
Randomized controlled trial
- From:
Chinese Journal of Pharmacoepidemiology
2025;34(2):144-150
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy of Penyan pill combined with thunder fire moxibustion(TFM)in patients with sequelae of pelvic inflammatory disease(SPID).Methods This study was conducted at the department of gynecology,the First Affiliated Hospital of Hunan University of Traditional Chinese Medicine from May 2023 to May 2024.Patients with SPID were recruited and randomly and equally divided into group A(treated with ornidazole),group B(treated with ornidazole combined with Penyan pill),and group C(treated with ornidazole combined with Penyan pill and TFM).The primary outcome was the treatment effective rate,the secondary indicators were the Traditional Chinese Medicine Syndrome Integral(TCMSI),Visual Analogue Scale(VAS)score,short-form 36 health survey(SF-36)score,Self-rating Anxiety Scale(SAS)score,inflammatory factors[interleukin-6(IL-6),tumor necrosis factor(TNF-α),and C-reactive protein(CRP)],and the incidence of adverse drug reactions.All observation indicators were evaluated before treatment and 12 weeks after treatment.Results A total of 195 patients with SPID were included,and 16 patients failed to complete the study due to poor compliance.Therefore,the final number of cases was 59 in group A,60 in group B,and 60 in group C.The treatment effective rate in group C was 95.00％,which was significantly higher than that in group B(80.00％)and group A(71.19％)(P＜0.017).However,there was no significant difference in the effective rates between group A and group B(P＞0.017).After treatment,the TCMSI total score,VAS score,SF-36 score,SAS score,and the levels of serum IL-6,TNF-α,and CRP in the three groups were significantly improved compared with those at enrollment(P＜0.05).In addition,all the indicators in group C were significantly better than those in group B and group A(P＜0.05).No adverse reactions were observed in the three groups.Conclusion Penyan pill combined with TFM can improve the pain degree,quality of life and anxiety state in SPID patients,which may be related to the regulation of inflammatory factor expression.
