One case of epileptic-like seizures induced by isavuconazole
10.12173/j.issn.1005-0698.202408078
- VernacularTitle:注射用艾沙康唑致癫痫样发作1例分析
- Author:
Qiao GUO
1
;
Pei LIANG
Author Information
1. 南京市江宁医院药学部(南京 211100)
- Publication Type:Journal Article
- Keywords:
Isavuconazole;
Epileptic-like seizures;
Blood drug concentration;
Adverse drug reaction
- From:
Chinese Journal of Pharmacoepidemiology
2025;34(1):116-120
- CountryChina
- Language:Chinese
-
Abstract:
A 37-year-old patient with pulmonary mucormycosis who developed epileptic-like seizures during treatment with isavuconazole.The patient had multiple comorbidities,including hypoalbuminemia,hepatic dysfunction,and renal insufficiency and displayed normal mental status before treatment.However,after 27 days of isavuconazole therapy,the patient experienced a sudden onset of unresponsiveness,absence seizures,and body rigidity.Therapeutic drug monitoring revealed a plasma trough concentration of isavuconazole at 6.4 mg·L-1,the epileptic-like seizures were suspected to be caused by neurotoxicity due to elevated isavuconazole plasma levels.The drug was immediately discontinued,and no further seizures occurred.The Naranjo's Assessment Scale was used to evaluate the association between adverse reactions and isavuconazole,and the result was"probably relevant".This case highlights the need for caution regarding the potential adverse reaction of seizures when using isavuconazole in clinical practice.This case suggests that clinical use of isavuconazole should be auompanied by vigilance epileptic-like adverse events.Pharmaceutical care and timely analysis of medication use should be carried out,and appropriate symptomatic management should be provided promptly in case of any adverse events.
