Clinical Characteristics of Hospitalized Children with Pertussis Stratified by Vaccination Status
10.11969/j.issn.1673-548X.2025.06.015
- VernacularTitle:不同疫苗接种状态儿童百日咳住院患儿的临床特征分析
- Author:
Limin KANG
1
;
Rong MI
;
Yajuan WANG
Author Information
1. 100020 北京,首都儿科研究所附属儿童医院新生儿内科
- Publication Type:Journal Article
- Keywords:
Pertussis;
Pertussis vaccine;
Children;
Clinical Characteristics
- From:
Journal of Medical Research
2025;54(6):82-86
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical characteristics of hospitalized children with pertussis based on their pertussis vacci-nation status.Methods From March,2011 to February,2022,children with pertussis hospitalized at the Children's Hospital Affiliated to Capital Institute of Pediatrics were retrospectively selected.Information was analyzed regarding demographic data and clinical data,Pa-tients were divided into three groups based on vaccination status:non-vaccinated,incompletely vaccinated(1dose or 2doses),and com-pletely vaccinated(3doses).Clinical features were compared among the groups.Results A total of 270 children hospitalized with pertus-sis were included.The non-vaccinated group comprised 206 cases(76.3％),the incompletely vaccinated group comprised 24 cases(8.9％),and the completely vaccinated group comprised 40 cases(14.8％).Statistically significant differences were observed in the overall age of onset among the three groups(P＜0.05),with the completely vaccinated group having the highest age of onset.Significant differences were also noted in the proportions of hypoxemia,decreased heart rate,paroxysmal cough,episodic cyanosis,facial flushing during coughing,and elevated peripheral blood lymphocyte proportion(≥0.6)across the groups(P＜0.05),with the completely vacci-nated group showing lower rates compared to the non-vaccinated group.Additionally,significant differences were observed in the rates of severe pertussis and the need for mechanical ventilation(invasive or non-invasive)among the groups(P＜0.05),with the completely vaccinated group having lower rates than the non-vaccinated group.Conclusion Complete vaccination,plays a critical role in allevia-ting clinical symptoms,reducing peripheral blood lymphocytosis,and decreasing the incidence of severe pertussis in children.
