Anti-vascular endothelial growth factor drugs for treatment of diabetes reti-nopathy:an umbrella review
10.13389/j.cnki.rao.2025.0020
- VernacularTitle:抗VEGF药物治疗糖尿病视网膜病变的伞状系统评价
- Author:
Juan LING
1
;
Jingnan GUAN
;
Xiangxia LUO
;
Zhuolin XIE
;
Xufei LUO
Author Information
1. 730030 甘肃省兰州市,甘肃中医药大学;730030 甘肃省兰州市,甘肃省人民医院
- Publication Type:Journal Article
- Keywords:
anti-vascular endothelial growth factor;
diabetes retinopathy;
umbrella review;
AMSTAR 2;
PRISMA
- From:
Recent Advances in Ophthalmology
2025;45(2):108-114
- CountryChina
- Language:Chinese
-
Abstract:
Objective To conduct an umbrella review of systematic studies/meta-analyses of anti-vascular endotheli-al growth factor(VEGF)drugs for the treatment of diabetes retinopathy(DR),to evaluate literature quality with AMSTAR 2 and PRISMA,and to show the distribution characteristics of evidence quality through both figures and tables.Methods Chinese and English databases including The Cochrane Library,PubMed,EMbase,CBM,Wanfang,and CNKI were searched on computer from the inception of the database up to March 2024 for the retrieval of systematic reviews/meta-ana-lyses on anti-VEGF drug therapy for DR treatment.Two evaluators read the literature and extract data separately before conducting an umbrella review of the methodological and reporting quality of the included literature using the AMSTAR 2 scale and PRISMA statement.Results 27 studies were ultimately included,and the methodological and reporting quality of systematic reviews/meta-analyses on anti-VEGF drugs for DR treatment was moderate-to-low.The evaluation by AM-STAR 2 showed that there was an urgent need to improve the elaboration of the pre-established research plan and funding sources included in the research.PRISMA results showed that items affecting reporting quality mainly included protocol and registration,literature search,supplementary analysis,and funding sources.Conclusion The methodological and repor-ting quality of systematic reviews/meta-analyses on anti-VEGF drug therapy for DR treatment needs to be improved.Re-searchers should strengthen methodological quality and reporting standards following the requirements of the AMSTAR 2 scale and PRISMA statement while writing systematic reviews/meta-analysis reports,so as to provide evidence with higher quality.
