Review of oral genetic diseases in China
10.3760/cma.j.cn112144-20250701-00240
- VernacularTitle:我国口腔遗传病研究回顾
- Author:
Jia LIANG
1
;
Zhuan BIAN
1
Author Information
1. 武汉大学口腔医（学）院 口颌系统重建与再生全国重点实验室 口腔生物医学教育部重点实验室口腔医学湖北省重点实验室，武汉 430079
- Publication Type:Journal Article
- Keywords:
Genetics;
Oral genetic diseases;
Gene;
Diagnosis;
Tooth;
Craniofacial
- From:
Chinese Journal of Stomatology
2025;60(9):951-958
- CountryChina
- Language:Chinese
-
Abstract:
This study provides a comprehensive review of the development and achievements in the field of oral genetic disorders research in China. Since the 1950s, Chinese scholars have progressed from epidemiological surveys to the elucidation of molecular mechanisms and functional genomics, marking a transition from macro-level observations to micro-level analyses. The research focuses on three major categories: cleft lip and palate, dental developmental anomalies, and rare hereditary oral diseases. Several critical pathogenic genes have been identified, and their molecular mechanisms and phenotypic characteristics elucidated. This paper summarizes representative findings, analyzes current challenges, and outlines future research directions, aiming to provide theoretical support for advancing both basic research and clinical translation in the field of oral genetics in China.
