Methylprednisolone-induced severe liver injury in an adult-onset Still's disease:a case report
10.12173/j.issn.1005-0698.202407047
- VernacularTitle:甲泼尼龙致成人斯蒂尔病患者严重肝损伤1例
- Author:
Jinmeng WANG
1
;
Wenfeng WU
;
Huiyi WU
Author Information
1. 南方医科大学南方医院临床药学中心(广州 510515);济南市人民医院药剂科(济南 271100)
- Publication Type:Journal Article
- Keywords:
Methylprednisolone;
Severe liver injury;
Adult-onset Still's disease;
Adverse drug reaction
- From:
Chinese Journal of Pharmacoepidemiology
2025;34(1):111-115
- CountryChina
- Language:Chinese
-
Abstract:
A 34-year-old male patient was diagnosed with adult-onset Still's disease.After treatment with methylprednisolone and tocilizumab,the levels of aminotransferase and bilirubin increased significantly,and decreased to normal levels after drug withdrawal and liver protective treatment.After the patient was treated with methylprednisolone again,the aminotransferase and bilirubin levels significantly increased.The treatment was changed from methylprednisolone to prednisolone,the levels of aminotransferase and bilirubin decreased significantly,the patient's condition improved and was discharged.Using the Naranjo Assessment Scale score of 9 points,the causal relationship between severe liver injury and methylprednisolone in this patient can be judged as"very likely".Clinical pharmacists conducted a comprehensive analysis of patients'medication usage and provided evidence-based recommendations for subsequent treatment regimens,thereby serving as a valuable reference for promoting rational drug use in clinical practice.
