Mechanism and prospects of regulatory B cells in transplantation immunotherapy
- VernacularTitle:调节性B细胞在移植免疫治疗中的机制及应用前景
- Author:
Yi BAI
1
;
Yanni ZHANG
1
;
Yuxin DUAN
1
;
Jinyao YU
1
;
Jiayi SUN
1
;
Zejie WANG
1
;
Ling LI
1
;
Qifa YE
1
Author Information
- Publication Type:Journal Article
- Keywords: B lymphocyte; Immunomodulation; Signal transduction; Transplantation tolerance
- From: Chinese Journal of Organ Transplantation 2025;46(4):317-323
- CountryChina
- Language:Chinese
- Abstract: Immunotherapy following transplantation has long been a central focus in both anti-rejection strategies and the induction of immune tolerance. Regulatory B cells (Bregs) can directly suppress the immune system via the interaction between programmed cell death protein 1 (PD-1) and its ligand programmed death ligand 1 (PD-L1). Additionally, Bregs exert indirect immunosuppressive effects through the secretion of cytokines such as interleukin-10 (IL-10), transforming growth factor-β (TGF-β), and granzyme B (GrB), among which IL-10 plays a particularly critical role. This review summarizes recent progress in the classification, functional characteristics, and activation mechanisms of Bregs, as well as their potential applications in transplantation immunotherapy, aiming to provide a theoretical foundation for Breg-targeted strategies in transplant immune modulation.
