Role of transient receptor potential vanilloid type 4 channel in skin diseases
- VernacularTitle:瞬时受体电位通道香草酸亚型4离子通道在皮肤病中的作用研究
- Author:
Jiayi SUN
1
;
Xiuzu SONG
1
Author Information
- Publication Type:Journal Article
- Keywords: Transient receptor potential channels; Skin diseases; Skin barrier; Itch; Transient receptor potential vanilloid type 4
- From: Chinese Journal of Dermatology 2024;57(12):1149-1152
- CountryChina
- Language:Chinese
- Abstract: Transient receptor potential vanilloid type 4 (TRPV4), the fourth member of the thermosensitive TRPV family, is a nonselective cation channel that is widely expressed in various tissues and cells. TRPV4 is involved in the physiological activities of various organs in the body by responding to both exogenous and endogenous stimuli. Studies have shown that TRPV4 participates in skin physiological and pathophysiological processes, including skin barrier repair and transduction of itch sensation, and also plays important roles in skin disorders, such as rosacea, alopecia, psoriasis, scleroderma, and skin cancers. This review summarizes research progress in the role of TRPV4 channels in skin diseases.
