The effects of Helicobacter pylori infection on the clinical characteristics of autoimmune gastritis
10.3760/cma.j.cn311367-20241106-00425
- VernacularTitle:幽门螺杆菌感染对自身免疫性胃炎临床特征的影响
- Author:
Wenbin LI
1
;
Xue XU
;
Hao LUO
;
Dan CHEN
;
Xi WU
;
Fangxu LIU
;
Qingfeng LUO
;
Jun DU
;
Zheng WANG
;
Jihua SHI
Author Information
1. 北京医院消化内科 国家老年医学中心 中国医学科学院老年医学研究院，北京 100730
- Publication Type:Journal Article
- Keywords:
Autoimmune gastritis;
Helicobacter pylori infection;
Endoscopic feature;
Pathological feature
- From:
Chinese Journal of Digestion
2025;45(6):369-375
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the differences in endoscopic and pathological features in autoimmune gastritis (AIG) patients with and without Helicobacter pylori ( HP) infection, and to explore the effects of HP on the clinical manifestations and disease development in AIG patients. Methods:From January 2022 to April 2024, 174 AIG patients who visited Beijing Hospital and met the 2022 AIG diagnostic criteria established by Japanese Gastroenterological Endoscopy Society were enrolled and divided into the HP-infected group (including current and previous infection, 77 cases) and the HP-unifected group (97 cases). The general clinical data, laboratory examinations endoscopic findings, and pathological characteristics of the two groups were analyzed. Independent sample t-test and chi-square test were used for statistical analyses. Results:The vitamin B 12 level of HP-infected group was higher than that of HP-unifected group ((573.81±460.77) ng/L vs. (411.86±335.00) ng/L), and the difference was statistically significant ( t=-2.57, P=0.011). The average red blood cell volume of HP-infected group was lower than that of HP-unifected group ((87.30±8.86) fL vs. (98.50±49.82) fL), and the difference was statistically significant ( t=2.16, P=0.033). The proportion of intestinal metaplasia in gastric fundus in HP-infected group was lower than that in HP-unifected group (50.6% (39/77) vs. 73.2% (71/97)), and the difference was statistically significant ( χ2=9.38, P=0.002). Conclusion:HP infection in AIG patients may delay the malabsorption of vitamin B 12 and the occurrence of intestinal metaplasia in gastric fundus.
