Recent advance in role of lysosomal ion channels in Alzheimer's disease
10.3760/cma.j.cn115354-20250207-00061
- VernacularTitle:溶酶体离子通道在阿尔茨海默病中的作用研究进展
- Author:
Zelin WU
1
;
Xiaolei LIU
1
Author Information
1. 山西医科大学第三医院/山西白求恩医院（山西医学科学院）/同济山西医院神经内科，太原 030032
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease;
Lysosome;
Ion channel protein;
Neurodegenerative disease;
Cognitive impairment
- From:
Chinese Journal of Neuromedicine
2025;24(8):838-844
- CountryChina
- Language:Chinese
-
Abstract:
Recent studies have shown that lysosomal dysfunction is closely related to Alzheimer's disease (AD). Lysosomal ion channels, such as transient receptor potential channel mucolipin-1, two-pore channel, and transmembrane protein 175, play an important role in maintaining lysosomal stability and reducing pathological protein accumulation, and are expected to become new targets for AD intervention and treatment. This article reviews the research progress on basic characteristics, physiological functions of the above lysosomal ion channels and their roles in AD, aiming to provide new targets and research perspectives for AD treatment.
