Recent advance in pathological impact of tenascin-C on Alzheimer's disease
10.3760/cma.j.cn115354-20241030-00659
- VernacularTitle:肌腱蛋白C对阿尔茨海默病病理影响的研究进展
- Author:
Huan MA
1
;
Jinshu WANG
1
;
Wei ZHANG
1
;
Zhantao BAI
1
;
Qinghu YANG
1
Author Information
1. 延安大学生命科学学院多肽药物研究中心，陕西省区域生物资源保护与利用工程技术研究中心，延安 716000
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease;
Tenascin C;
Extracellular matrix;
Neuroinflammation;
Synaptic dysfunction;
Autophagy dysregulation;
Amyloid β-protein
- From:
Chinese Journal of Neuromedicine
2025;24(8):833-837
- CountryChina
- Language:Chinese
-
Abstract:
Tenascin-C (TNC), an extracellular matrix glycoprotein, is lowly expressed in normal adult tissues while significantly upregulated under pathological conditions such as injury, inflammation, or tumors. Recent studies have shown that TNC plays an important role in Alzheimer's disease (AD) development: it is not only closely related to the formation of β-amyloid (Aβ) plaque, but also involved in neuroinflammation regulation and Aβ clearance process. This article reviews the effect of TNC on AD pathology in aspects of neuroinflammation, synaptic function, autophagy and Aβ load, aiming to provide theoretical basis for TNC-targeted AD treatment and drug development.
