Recent advance in application of amide proton transfer-weighted imaging in common central nervous system diseases
10.3760/cma.j.cn115354-20250227-00108
- VernacularTitle:酰胺质子转移加权成像在常见中枢神经系统疾病中的应用研究进展
- Author:
Runfa YOU
1
;
Zijie ZHAN
1
;
Xiaobei ZHOU
1
;
Wenjian LI
1
;
Binbin CHEN
1
;
Chao ZHENG
1
Author Information
1. 中南大学湘雅医学院附属常德医院（常德市第一人民医院）医学影像科，常德 415000
- Publication Type:Journal Article
- Keywords:
Amide proton transfer;
Chemical exchange saturation transfer;
Magnetic resonance molecular imaging;
Central nervous system;
Brain tumor;
Ischemic stroke;
Ne
- From:
Chinese Journal of Neuromedicine
2025;24(9):939-944
- CountryChina
- Language:Chinese
-
Abstract:
Amide proton transfer-weighted (APTw) imaging is a kind of new magnetic resonance molecular imaging that rapidly developed in recent years. APTw imaging reflects the protein concentration and acid-base changes in tissues by detecting amide protons in free proteins and peptides in tissues. APTw imaging is a complementary technique to the existing magnetic resonance techniques, which can provide new molecular biological information for central nervous system diseases. In this article, the basic principle of APTw imaging and its application in common central nervous system diseases such as brain tumor, ischemic stroke, and neurodegenerative diseases are reviewed to provide new methods for promoting the transformation of APTw imaging from the research stage to routine clinical application, and facilitating the precise diagnosis and treatment of central nervous system diseases.
