Impact of Interferon α-2b and CO2 Cryotherapy on Cervical Lesions
10.11969/j.issn.1673-548X.2025.01.021
- VernacularTitle:干扰素α-2b与CO2冷冻治疗对宫颈病变的影响
- Author:
Xuepeng NING
1
;
Jie HE
1
;
Pei WANG
1
Author Information
1. 050000 石家庄市第三医院妇产科
- Publication Type:Journal Article
- Keywords:
Cervical intraepithelial neoplasia;
Human papillomavirus;
Interferon α-2b;
CO2cryotherapy;
Immune markers;
In-flammation levels
- From:
Journal of Medical Research
2025;54(1):111-115
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study designed to evaluate the impact of interferon α-2b vaginal effervescent tablets in combination with CO2 cryotherapy on the immune markers and inflammation levels in patients with CIN and concurrent HPV infection,and to explore its potential effects in disease treatment.Methods A total of 124 patients with CIN and HPV infection,admitted to our hospital from 1st Jan 2023 to 18th Feb 2024,were selected and randomly divided into an observation group(Group B)and a control group(Group A),with 62 patients in each.The control group received only interferon α-2b vaginal effervescent tablets,while the observation group also underwent CO2 cryotherapy.The immune cell counts,cytokine levels,inflammation markers,and HPV-DNA quantification were as-sessed both before and after treatment.Results The observation group showed significant increase in immune cell counts(CD4+/CD8+)and cytokine levels(IFN-γ and TNF-α)after the treatment.Moreover,reductions in inflammation markers(CRP,IL-6 and IL-8)and a higher HPV clearance rate(67.74％)compared to the control group(45.16％),with a significantly lower recurrence rate(6.45％vs 16.12％),were observed.Conclusion The combination of interferon α-2b and CO2 cryotherapy have significantly in-creased the immune markers and reduced inflammation levels in patients with CIN and HPV,and effectively reduced the HPV recurrence rate.This combined treatment strategy presents an effective strategy for the management of precancerous cervical lesions.
