Recent advance in application of MRI in differential diagnosis of pseudoprogression and true progression of high-grade gliomas
10.3760/cma.j.cn115354-20250109-00015
- VernacularTitle:MRI在高级别脑胶质瘤假性进展与真实进展鉴别中的应用研究进展
- Author:
Ao LIU
1
;
Xizhen LI
;
Anqiang CHEN
;
Hao YU
Author Information
1. 济宁医学院临床医学院，济宁 272029
- Publication Type:Journal Article
- Keywords:
Glioma;
Magnetic resonance imaging;
Pseudoprogression;
True progression
- From:
Chinese Journal of Neuromedicine
2025;24(6):630-636
- CountryChina
- Language:Chinese
-
Abstract:
Distinguishing pseudoprogression (PsP) from true progression (TP) in patients with high-grade gliomas after treatment remains a critical challenge, as their appearances on conventional MRI are often similar. Accurate differentiation between the two is of great clinical significance for guiding and adjusting therapeutic strategies. MRI functional imaging can reveal key tissue characteristics such as water molecule diffusion, microvascular perfusion, and metabolic changes within lesions after treatment, thereby providing valuable objective evidences for differentiating PsP from TP. Especially in recent years, the radiomics analysis method based on large-scale MRI image data has further improved the accuracy in distinguishing PsP from TP. This article reviews the research progress on applications of various MRI techniques and combination of radiomics with other artificial intelligence methods in differentiating PsP from TP in high-grade gliomas, aiming to enhance the clinicians' understanding of differential diagnosis of PsP and TP in high-grade gliomas, and offer ideas and directions for emerging MRI application in this field.
