Study on the differences in dual-energy CT findings and clinical and laboratory indicators of frequent versus infrequent gout flares in the feet and ankles
10.3969/j.issn.1002-1671.2025.07.021
- VernacularTitle:频发型与偶发型痛风足踝部双能CT征象与临床及实验室指标的差异性研究
- Author:
Meihan CHEN
1
;
Pei NIE
;
Xiaoli LI
;
Tong YU
;
Fengjiao LI
;
Changgui LI
;
Ying CHEN
;
Lin HAN
;
Wenjian XU
Author Information
1. 青岛大学附属医院放射科,山东 青岛 266003
- Publication Type:Journal Article
- Keywords:
gout flare;
frequency;
dual-energy computed tomography;
risk factor;
bone erosion
- From:
Journal of Practical Radiology
2025;41(7):1177-1181,1233
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the differences in the radiological features,clinical,and laboratory indicators of frequent versus infrequent gout flares in the feet and ankles using dual-energy computed tomography(DECT).Methods A retrospective selection was made on 385 gout patients,who were divided into the frequent flare group(≥2 gout attacks per year,219 cases)and the infre-quent flare group(<2 gout attacks per year,166 cases).Clinical data,laboratory indicators,and DECT imaging findings were col-lected for statistical analysis.Binary logistic regression was used to analyze the independent risk factors for frequent gout flares and receiver operating characteristic(ROC)curve was plotted.Results Statistically significant differences were found between the fre-quent flare group and the infrequent flare group in terms of disease duration,body mass index(BMI),blood pressure,triglyceride(TG),serum uric acid(SUA),monosodium urate(MSU)crystal deposition,total volume of MSU crystals,maximum diameter of individ-ual tophi,number of affected joints,bone erosion,maximum depth of bone erosion,soft tissue swelling,bone proliferation and sclero-sis,and joint space narrowing(P<0.05).SUA levels,MSU crystal deposition,total volume of MSU crystals,and maximum depth of bone erosion were identified as independent risk factors for frequent gout(P<0.05).Both the combination of four factors model and the maximum depth of bone erosion model had better diagnostic efficacy.Conclusion Gout patients with high SUA levels,MSU crystal deposition,larger total volume of MSU crystals,and greater maximum depth of bone erosion are more likely to experience frequent gout attacks.Patients with bone erosion depth>3.200 mm are more likely identified early as having frequent gout.
