Recent advance in regulatory role of cannabinoid receptor in Alzheimer's disease
10.3760/cma.j.cn115354-20250530-00313
- VernacularTitle:大麻素受体在阿尔茨海默病中的调控作用研究进展
- Author:
Bin YANG
1
;
Zhenzhen FAN
;
Rong PAN
;
Hongbin CAI
Author Information
1. 兰州大学第二医院神经内科，兰州 730030
- Publication Type:Journal Article
- Keywords:
Cannabinoid receptor;
Alzheimer's disease;
Neurodegenerative disease;
Amyloid beta-protein metabolism;
Inflammatory injury;
Oxidative stress;
Synaptic plast
- From:
Chinese Journal of Neuromedicine
2025;24(11):1169-1173
- CountryChina
- Language:Chinese
-
Abstract:
Studies have shown that cannabinoid receptor (CBR) influence the onset and progression of Alzheimer's disease (AD) by participating in several key pathological processes, including β-amyloid protein (Aβ) metabolism, tau protein phosphorylation, neuroinflammation, oxidative stress, autophagy, and synaptic plasticity, which suggests that CBR may represent a potential novel therapeutic target for AD. This article reviews the recent advance in the regulatory role of CBR in AD, aiming to provide theoretical basis for AD treatment.
