Safety and efficacy analysis of the effects of intermittent theta rhythm stimulation on cortical excitability and upper limb motor function in patients with stroke at recovery stage
10.3969/j.issn.1001-1242.2025.07.009
- VernacularTitle:间歇性θ节律刺激对脑卒中恢复期患者大脑皮质兴奋性及上肢运动功能影响的安全性及有效性分析
- Author:
Tianxiang ZHANG
1
;
Wenbin JI
1
;
Yujing MA
1
Author Information
1. 山东大学齐鲁医院(青岛)康复科,山东省 青岛市,266000
- Publication Type:Journal Article
- Keywords:
intermittent theta burst stimulation;
stroke;
cortical excitability;
upper limb motor function
- From:
Chinese Journal of Rehabilitation Medicine
2025;40(7):1033-1039
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Exploring the safety and efficacy of intermittent theta rhythm stimulation on cortical excitability and upper limb motor function in patients with stroke at recovery stage.Method:From January,2022 to April 2023,30 patients with stroke at recovery stage who received rehabilita-tion treatment were randomly divided into the experimental group(n=15)and the control group(n=15)using the random number method.Both groups were subjected to routine rehabilitation training.The experimental group was given additional intermittent theta rhythm stimulation on the basis of routine rehabilitation,and the control group added intermittent theta rhythm sham stimulation,5 times a week for 4 weeks.Neurophysiologic indexes were tested on both the healthy and affected sides of the patients in the 2 groups before and after the intervention,as well as the assessment of upper limb motor function.Result:After 4 weeks of intervention,there were no statistical differences in MEP maximum wave ampli-tude,MEP latency,CMCT value,CSP value and RMT value of the healthy side between before and after in-tervention and between the groups(P>0.05);MEP maximum wave amplitude of the affected side of the experi-mental group was higher than before intervention(P<0.05);the affected side of the experimental group had a low-er MEP latency,CSP value,and RMT value than before intervention and the control group(P<0.01,P<0.05).Fugl-Meyer upper limb function scores,MBI scores,grip strength on the affected side,and nine-hole post time spent in the experimental group improved after the intervention compared to before the intervention(P<0.01,P<0.05).Fugl-Meyer upper extremity function scores,MBI scores,and time spent on the affected side of the nine-hole column improved in the experimental group after the intervention compared to the control group(P<0.01,P<0.05).Conclusion:Intermittent theta rhythm stimulation combined with conventional rehabilitation training did not show significant effects on the cortical excitability of the healthy side of patients with stroke at recovery stage.However,it could improve the cortical excitability of the affected side of patients with stroke at recovery stage and improve the motor function of the upper limbs.
