Recent advance in pathogenesis and treatment of hypothalamic obesity
10.3760/cma.j.cn115354-20250718-00414
- VernacularTitle:下丘脑性肥胖症的发病机制和治疗研究进展
- Author:
Kang WANG
1
;
Hui ZHAO
Author Information
1. 山东第一医科大学第二附属医院神经内科，泰安 271000
- Publication Type:Journal Article
- Keywords:
Hypothalamic obesity;
Arcuate nucleus;
Neuronal perineuronal net;
Leptin;
Sympathetic nervous system
- From:
Chinese Journal of Neuromedicine
2025;24(10):1073-1079
- CountryChina
- Language:Chinese
-
Abstract:
Hypothalamic obesity (HO) is a syndrome characterized by metabolic abnormalities and weight gain resulting from structural or functional abnormalities of the hypothalamus (such as tumors, surgery, trauma, inflammation, or congenital diseases). In recent years, with the in-depth research in neuroscience, endocrinology, and genetics, there have been new advancements in pathogenesis and treatment strategies of HO. This article reviews the recent advance in pathogenesis and treatment of HO from aspects as dysregulation of neuroendocrine pathways, blood-brain barrier dysfunction, genetic abnormalities, and gut-liver-brain axis abnormalities, with the aim of providing new directions for HO precise treatment.
