Recent advance in treatment of meningeal metastasis from solid tumors
10.3760/cma.j.cn115354-20250613-00340
- VernacularTitle:实体瘤脑膜转移的治疗研究进展
- Author:
Zengfeng SUN
1
;
Chunhua SHE
1
;
Peng LI
1
;
Wenliang LI
1
;
Xiaoguang WANG
1
Author Information
1. 天津医科大学肿瘤医院脑系肿瘤科，国家恶性肿瘤临床医学研究中心，天津市肿瘤防治重点实验室，天津市恶性肿瘤临床医学研究中心，天津 300060
- Publication Type:Journal Article
- Keywords:
Meningeal metastasis;
Solid tumor;
Intrathecal chemotherapy;
Targeted therapy;
Proton radiotherapy
- From:
Chinese Journal of Neuromedicine
2025;24(10):1064-1072
- CountryChina
- Language:Chinese
-
Abstract:
Meningeal metastasis is a kind of serious complications of malignant tumor cells invading the leptomeninges and spreading along the cerebrospinal fluid, whose detection rate is gradually increased with advanced imaging diagnostic techniques. Although traditional intrathecal chemotherapy can prolong the survival of patients with meningeal metastasis, its efficacy is still unsatisfactory. In recent years, new intrathecal injection regimens, targeted drug therapy, and proton radiotherapy have significantly improved the prognosis of some patients with meningeal metastasis; however, these treatment regimens still require high-quality evidence-based medical evidences. This article reviews the recent advance in intrathecal injection, systemic treatments (systemic chemotherapy, molecular targeted therapy and immunotherapy), and radiotherapy of meningeal metastasis in recent years, so as to help selecting treatment regimens for meningeal metastasis in clinical practice.
