Recent advance in role of cytokines in myasthenia gravis
10.3760/cma.j.cn115354-20250414-00214
- VernacularTitle:细胞因子在重症肌无力中的作用研究进展
- Author:
Chunkai LI
1
;
Yuanyin TENG
;
Junxiong YIN
Author Information
1. 南京医科大学附属脑科医院神经内科，南京 210029
- Publication Type:Journal Article
- Keywords:
Myasthenia gravis;
Cytokine;
Interleukin-4;
Interleukin-6;
Interleukin-17;
Transforming growth factor-β;
Satralizumab
- From:
Chinese Journal of Neuromedicine
2025;24(10):1048-1052
- CountryChina
- Language:Chinese
-
Abstract:
Myasthenia gravis (MG) is mainly mediated by pathogenic autoantibodies secreted by effector B cells. Cytokines secreted by various immune cells can participate in MG development by regulating B lymphocyte activity and modulating lymphocyte differentiation. This article reviews the recent advance in role of cytokines such as interleukin (IL)-4, IL-6, IL-17, and transforming growth factor-β in MG development and cytokine-targeted MG treatment, with the aim of providing new ideas for MG diagnosis, treatment, and prognosis assessment.
