Recent advance in role and mechanism of CD11c + microglia in central nervous system development and diseases
10.3760/cma.j.cn115354-20250401-00184
- VernacularTitle:CD11c +小胶质细胞在中枢神经系统发育和疾病中的作用及机制研究进展
- Author:
Mei HAN
1
;
Yifan JIANG
1
;
Hui YUAN
1
Author Information
1. 山东第一医科大学第二附属医院神经内科，泰安 271000
- Publication Type:Journal Article
- Keywords:
CD11c + microglia;
Central nervous system development;
Central nervous system disease;
Neuroprotection;
Phagocytic clearance;
Immune regulation
- From:
Chinese Journal of Neuromedicine
2025;24(10):1040-1047
- CountryChina
- Language:Chinese
-
Abstract:
CD11c + microglia are a type of important immune cells in the central nervous system. They maintain the homeostasis of internal environment during normal development and are massively activated in aging and various neuro-pathological conditions, playing roles in phagocytic clearance and neuroinflammation regulation; however, their specific mechanism remains unclear. In recent years, more and more studies have focused on mechanism of this cell subpopulation in the central nervous system development and diseases. Therefore, this article reviews the recent advance in the biological characteristics, signal regulation mechanisms of CD11c + microglia, as well as their roles in neurodevelopment and various CNS diseases (ischemic stroke, traumatic brain injury, neuropathic pain, Alzheimer's disease, Parkinson's disease, multiple sclerosis and neuromyelitis optica), aiming to provide theoretical basis and reference for the development of drugs targeting CD11c + microglia.
