Impact of Drug Gene Testing Guidance on Individualized Medication for First-episode Schizophrenia Patients
10.11969/j.issn.1673-548X.2025.01.018
- VernacularTitle:药物基因检测指导个体化用药对首发精神分裂症患者的影响
- Author:
Haigang LIU
1
;
Teng LI
;
Rui ZHAO
Author Information
1. 063000 唐山,开滦总医院精神科
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Starting;
Drug gene testing;
Individualized medication;
The prognosis of the disease
- From:
Journal of Medical Research
2025;54(1):97-101
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the impact of drug gene testing guidance on individualized medication for first-episode schizo-phrenics.Methods A total of 120 patients with first-episode schizophrenia received in our hospital were randomly divided into a control group(receiving drug treatment based on doctors'experience)and experimental group(receiving treatment based on drug gene testing),with 60 patients in each group.After 3 years of following-up,the changes in condition,adverse reactions,treatment compliance,family and social functions,and quality of life of the two groups of patients were compared.Results When discharged from the hospital,1 year and 3 years later,the total score of the positive and negative symptom scale(PANSS)in the experimental group was lower than that in the control group(t were 2.001,2.142,3.527;P were 0.048,0.034,0.001);the scores of adverse reaction scale(UKU)in the experi-mental group were lower(t were 2.914,3.473,3.429;P were 0.004,0.001,0.001),and the scores of drug attitude scale(DAI)were higher than those in the control group(t were 2.687,2.865,2.447;P were 0.008,0.005,0.016);the scores of family function scale(FAD)in the experimental group were higher(t were 2.088,2.607,2.088;P were 0.039,0.010,0.039),and the scores of social dysfunction screening scale(SDSS)were lower(t were 3.594,2.999,3.204;P were＜0.001,0.003,0.002).The total score of schizo-phrenia quality of life scale(SQLS)in the experimental group was lower than that in the control group(t were 2.754,2.523,2.493;P were 0.007,0.013,0.014).Conclusion After three years of follow-up,the results show that drug gene testing can promote the progno-sis of first-episode schizophrenia patients,reduce adverse reactions,improve treatment compliance,and enhance the functions of family and society and quality of life.
