Recent advance in TREM2 regulation in intervening Alzheimer's disease
10.3760/cma.j.cn115354-20250317-00150
- VernacularTitle:调控TREM2干预阿尔茨海默病的研究进展
- Author:
Yufan WANG
1
;
Yifan WANG
Author Information
1. 南京中医药大学中西医结合学院，南京 210023
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease;
TREM2;
Microglia;
Amyloid β-protein;
Neuroinflammation;
Targeted therapy
- From:
Chinese Journal of Neuromedicine
2025;24(9):952-958
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by β-amyloid (Aβ) and tau protein deposition. Microglia are important immune cells in the brain. In the early stage of AD, they play a protective role by clearing AB deposits, but in the late stage, they may aggravate the pathological manifestations of AD through ways such as enhancing neuroinflammation. Triggering receptor expressed on myeloid cell 2 (TREM2), as a core immunomodulatory factor of microglia, maintains the metabolic homeostasis in the brain by bidirectionally regulating Aβ plaque clearance and neuroinflammatory responses through activating downstream signaling pathways. This article reviews the recent advance in structure and function of TREM2 and its role in the pathology and targeted therapy of AD, in order to provide new thoughts for AD treatment targeting TREM2.
