Functional MRI study on the effects of different daily doses of methadone on the brain response of heroin addicts under drug cues
10.3969/j.issn.1002-1671.2025.07.001
- VernacularTitle:不同日均剂量美沙酮对海洛因成瘾者毒品线索下大脑反应影响的功能MRI研究
- Author:
Hanyue WANG
1
;
Ning WU
;
Jiajie CHEN
;
Fan WANG
;
Qiang LI
;
Wei WANG
Author Information
1. 中国人民解放军总医院京中医疗区安宁庄门诊部,北京 100085
- Publication Type:Journal Article
- Keywords:
heroin addiction;
methadone maintenance treatment;
functional magnetic resonance imaging;
caudate nucleus
- From:
Journal of Practical Radiology
2025;41(7):1081-1084
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of different daily doses of methadone maintenance treatment(MMT)on subjective craving and brain function under drug cues among heroin addicts,providing an objective basis for the formulation of methadone medi-cation plan in clinical practice.Methods Twenty-nine heroin addicts were included and grouped according to the daily dose of metha-done 40 mg,≤40 mg/d group 15 participants(group A),>40 mg/d group 14 participants(group B).The functional magnetic reso-nance imaging(fMRI)data of brain response induced by drug cues were collected using a 3.0T MR scanner,and the craving data induced by drug cues in the subjects were collected.Brain activity and behavioral data processing were analyzed using SPM8 and SPSS 20.0 software.Results There were no statistically significant differences in craving scores between the two groups of subjects exposed to drug cues(t=-0.69,P>0.05).The brain regions with differences in brain response included the left caudate nucleus(group A showed signifi-cantly enhanced response),and the strength of its response was negatively correlated with the daily dose of methadone(r=-0.465,P=0.025).Conclusion Higher doses of MMT may help control the value cognitive processing of drug cues in heroin addicts through the caudate nucleus,which can better prevent relapse.In the future,the degree of activation of the caudate nucleus under drug cues may serve as an indicator for evaluating the effectiveness of methadone treatment.
