Establishment of A Quality Evaluation Model of Huangjing Dami Pills Based on Physical Properties Characterization and Its Application in Formulation Process Optimization
10.11842/wst.20240905002
- VernacularTitle:基于物性表征的黄精大蜜丸质量评价模型的建立及在处方工艺优化中的应用
- Author:
Yueyuan XU
1
;
Xinyu WU
1
;
Zehua LIANG
1
Author Information
1. 浙江中医药大学 杭州 311400
- Publication Type:Journal Article
- Keywords:
Big honey pill;
Physical attributes;
Index nature;
Principal component analysis;
AHP-CRITIC weight evaluation method;
Extreme value method;
Optimal value method
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2025;27(7):2050-2062
- CountryChina
- Language:Chinese
-
Abstract:
Objective Based on the holistic view of traditional Chinese medicine,a more objective and comprehensive quality evaluation model for Huangjing Dami pills was established by combining external traits and internal qualities,and was applied to the optimization of the prescription process to verify its feasibility and applicability,so that it can provide reference for the optimization of the preparation process of other honey pills.Methods The texture characterization information of Huangjing Dami pills was collected based on the texture meter,and the water content and chemical composition information were collected based on the 2020 edition of the Chinese Pharmacopoeia.Given that the hardness and other texture characterization indexes are moderate indexes,the quality evaluation model established by the polar value method and principal component analysis(PCA)was used to quantify the values of the characterization evaluation indexes,which can be used to screen the significance of the influencing factors in the Plackett-Burman(PB)test;The quality evaluation model based on the optimal value method,the polar value method and the Analytic Hierarchy Process(AHP)-CRITIC method was used to characterize the quantification of the actual values of the evaluation indexes,and it can be used to optimize the process and derive the optimal process parameters for the steepest hill-climbing test,the response surface test and the validation test.Results The quality evaluation model based on the extreme value method-PCA was used in the PB test to screen out the three significant influencing factors of the ratio of honey to medicine,drying temperature and mesh number;the quality evaluation model based on the optimal value,extreme value method-AHP-CRITIC method was used in the steepest climb test,response surface test and validation test,which resulted in the optimal prescription process parameters of Huangjing Dami pills,namely,the ratio of medicine to honey was 1:0.64,the honey temperature was 60℃,the mesh number was 100 mesh,the drying temperature was 50.8℃,the drying time was 3 h,the sweating time was 1 day.Conclusion It was verified that the feasibility and applicability of the qualitative attributes guiding the optimization of prescriptions,and that the established quality evaluation model could guarantee the quality of the final product by taking into account the physical attributes and the chemical attributes during the optimization of the prescription,which showed a better prospect of application in the optimization of the process of honey pills and the method for the evaluation of the quality of honey pills preparation.
