Senescence-associated secretory phenotype and pyroptosis in adamantinomatous craniopharyngioma
10.3760/cma.j.cn115354-20250321-00160
- VernacularTitle:造釉细胞型颅咽管瘤中衰老相关分泌表型及细胞焦亡调控机制的研究进展
- Author:
Jiacheng TAN
1
;
Wenhao AN
1
;
Jing FENG
1
;
Xueling QI
1
;
Zhixiong LIN
1
Author Information
1. 首都医科大学三博脑科医院神经外科，北京 100093
- Publication Type:Journal Article
- Keywords:
Adamantinomatous craniopharyngioma;
Tumor microenvironment;
Senescence-associated secretory phenotype;
Pyroptosis;
NLRP3 inflammasome;
Beta-catenin
- From:
Chinese Journal of Neuromedicine
2025;24(7):720-727
- CountryChina
- Language:Chinese
-
Abstract:
Adamantinomatous craniopharyngioma (ACP) is an epithelial tumor originating from remnants of Rathke's pouch. A highly inflammatory microenvironment and histological presence of the senescence-associated secretory phenotype (SASP) are key pathological features of ACP. Pyroptosis, an inflammatory form of programmed cell death, forms a positive feedback loop with SASP, mutually promoting their effects. This review summarizes the current research progress on regulatory mechanism of SASP and pyroptosis in ACP so as to further understand the pathophysiological mechanisms underlying ACP development.
