Application and challenge of cerebral organoid in acute brain injury
10.3760/cma.j.cn115354-20250226-00103
- VernacularTitle:脑类器官在急性脑损伤中的应用与挑战
- Author:
Bohan ZHANG
1
;
Pei WU
;
Yuchen LI
;
Linlu TIAN
;
Shancai XU
;
Huaizhang SHI
Author Information
1. 哈尔滨医科大学附属第一医院神经外科，哈尔滨 150001
- Publication Type:Journal Article
- Keywords:
Cerebral organoid;
Acute brain injury;
Disease modeling;
Drug development;
Regenerative medicine
- From:
Chinese Journal of Neuromedicine
2025;24(7):711-719
- CountryChina
- Language:Chinese
-
Abstract:
At present, acute brain injuries such as stroke and traumatic brain injury have become a serious burden on public health due to relatively limited treatment methods. As an emerging three-dimensional cell culture model, cerebral organoid can well redisplay the cellular diversity, tissue structure and functional characteristics of the human brain, providing an ideal platform for disease modeling, drug development and regenerative medicine research of acute brain injury. However, the construction and application of cerebral organoid are still in the exploratory stage at present, facing major technical bottlenecks such as insufficient vascularization, lack of immune microenvironment and tissue heterogeneity. This review summarizes the cultivation technique of cerebral organoid, highlights its application in acute brain injury, and analyzes its current technical bottleneck, so as to provide more reference basis for the development and application of this technology.
