Recent advance in ion channel genes in co-morbidity of epilepsy and arrhythmia
10.3760/cma.j.cn115354-20250109-00014
- VernacularTitle:离子通道基因在癫痫与心律失常共患病中的研究进展
- Author:
Wenjie HAN
1
;
Junjie BAN
1
;
Zhensheng LI
1
;
Bingmei DENG
1
Author Information
1. 解放军南部战区总医院神经内科，广州 510010
- Publication Type:Journal Article
- Keywords:
Epilepsy;
Arrhythmia;
Ion channel gene;
Comorbidity;
Electrophysiological characteristic
- From:
Chinese Journal of Neuromedicine
2025;24(7):728-733
- CountryChina
- Language:Chinese
-
Abstract:
The co-occurrence of epilepsy and arrhythmia is an increasingly concerned research area, but the underlying biological mechanism is still not fully understood. In recent years, many studies have focused on how mutations in ion channel genes affect the electrophysiological properties of neurons and heart muscle cells, revealing a possible intersection between epilepsy and arrhythmia. Mutations in ion channel genes (such as SCN1A, KCNQ2, and RYR2) may simultaneously affect the electrophysiological properties of neurons and cardiomyocytes, leading to the comorbidity of epilepsy and arrhythmia. During epileptic seizures, activation of the autonomic nervous system may cause abnormal cardiac electrical activity, increasing risks of arrhythmia and sudden death resulting from epilepsy. In addition, the potential effects of antiepileptic drugs on cardiac ion channels can further increase the arrhythmia risk. This article reviews the research progress on the electrophysiological characteristics of ion channels in neurons and cardiomyocytes, the relations of ion channel gene mutations with epilepsy, arrhythmia, and their comorbidity, with the aim of providing new ideas for clinical diagnosis and treatment of epilepsy.
