Recent advance in mechanism of lactylation modification in central nervous system diseases
10.3760/cma.j.cn115354-20241114-00714
- VernacularTitle:蛋白质乳酸化修饰在中枢神经系统疾病中的作用机制研究进展
- Author:
Xueqi WANG
1
;
Mei YANG
1
;
Jin TANG
1
;
Yajing FENG
1
;
Feng ZHU
1
Author Information
1. 同济大学附属东方医院重症医学科，上海 200120
- Publication Type:Journal Article
- Keywords:
Lactylation modification;
Central nervous system disease;
Neuroinflammation;
Oxidative stress;
Glycolysis
- From:
Chinese Journal of Neuromedicine
2025;24(7):746-752
- CountryChina
- Language:Chinese
-
Abstract:
Lactate, the end product of glycolysis within the central nervous system (CNS), functions not only as a crucial neuronal energy source but also as a potent signaling molecule. Recently, lactate-mediated protein lactylation has been recognized as a novel post-translational modification influencing CNS pathophysiology. Lactate-mediated protein lactoylation modification regulates key pathological processes such as neuroinflammation and oxidative stress by modulating the structure and function of histones and non-histones, thereby influencing the occurrence and development of CNS diseases. This article reviews the research progress on mechanism of lactylation modification in CNS diseases, aiming to explore the regulatory potential of lactylation modification in CNS diseases and provide new ideas for the study of CNS diseases.
