An Exploration of the Influence and Mechanism of Liver Failing to Convey and Disperse on Age-Related Changes in Attentional Search Based on ERPs
- VernacularTitle:基于ERPs探讨肝失疏泄对注意搜索年老化的影响及机制
- Author:
Yan ZHANG
1
;
Lan ZHAO
;
Yong LIU
;
Junlin HOU
;
Jinchai DENG
;
Lei HUO
;
Zhongpeng QIN
;
Wenju ZHANG
;
Xianghong ZHAN
Author Information
- Publication Type:Journal Article
- Keywords: Attention search; Neuroticism; Event-related potentials; Liver failing to convey and disperse
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2025;27(7):1946-1956
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the influence of the and mechanism of liver failing to convey and disperse on age-related changes in attentional search based on ERPs.Methods oddball attention search task was administrated to record and analyze behavioral and EEG data(N2pc、SPCN、N2pc-Ptc components)of 120 subjects.Results Compared with liver controlling conveyance and dispersion group,the accuracy in subjects with liver failing to convey and disperse decreased significantly(P<0.05).The elderly group had a lower accuracy(P<0.001)and a longer reaction time(P<0.001)compared to the young group.The N2pc amplitude in subjects with liver failing to convey and disperse was significantly greater than that in subjects with liver controlling conveyance and dispersion(P<0.05).The interaction effect of SPCN amplitude between age and liver failing to convey and disperse status was significant(P=0.024).And in the elderly group,SPCN amplitude in subjects with liver dysregulation was significantly smaller than that of liver controlling conveyance and dispersion(P=0.042).The N2pc-Ptc peak to peak amplitude interaction effect between age and liver regulation status was marginal significant(P=0.087),and in liver failing to convey and disperse group,N2pc-Ptc peak to peak amplitude of the elderly was significantly smaller than that of the young(P=0.008).Conclusion Attention search ability is impaired in the elderly with liver failing to convey and disperse,and the electrophysiological abnormalities,such as directed attention allocation,spatiotemporal dynamic cohesion and short-term memory maintenance,may be part of the mechanism.
