Recent advance in central nervous system changes in diabetic peripheral neuropathy
10.3760/cma.j.cn115354-20250110-00019
- VernacularTitle:糖尿病性周围神经病中枢神经系统改变的研究进展
- Author:
Ze ZHANG
1
;
Jiaxin LIU
;
Zhenxuan GAO
;
Qi WANG
;
Wenqiang YANG
;
Yanbing YU
;
Li ZHANG
Author Information
1. 北京大学中日友好临床医学院，北京 100029
- Publication Type:Journal Article
- Keywords:
Diabetic peripheral neuropathy;
Multimodal MRI;
Functional MRI;
Central nervous system
- From:
Chinese Journal of Neuromedicine
2025;24(6):609-615
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic peripheral neuropathy (DPN) is one of the common chronic complications of diabetes, presenting with neuropathic pain, sensory abnormalities, and sensory loss, and may lead to foot infections, ulcers, or amputation in severe cases. Its pathogenesis remains unclear, with challenge in early diagnosis and limited treatment efficacy. Emerging evidences suggest that DPN involves in not only the peripheral nervous system but also the central nervous system (CNS). With advances in imaging technologies, multimodal MRI has become a key tool to investigate CNS involvement in DPN. This review summarizes the structural, functional, metabolic, and perfusion-related CNS changes in DPN patients based on structural MRI, functional MRI, MR spectroscopy, and perfusion-weighted imaging, aiming to help early detection, clinical subtyping, and personalized treatment of DPN.
