Neuropathological characteristics of autopsy brain tissues in schizophrenia patients
10.3760/cma.j.cn115354-20250630-00380
- VernacularTitle:精神分裂症患者尸检脑组织神经病理学特征研究
- Author:
Keqing ZHU
1
;
Peiran JIANG
1
;
Bing SUN
1
;
Zheng FANG
1
;
Juanli WU
1
;
Jianxin LIU
1
;
Cuiyun LIU
1
;
Yuting HU
1
;
Yi SHEN
1
;
Jing ZHANG
1
Author Information
1. 浙江大学医学院国家健康与疾病人脑组织资源库，杭州 310058
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Alzheimer's disease neuropathological change;
Cerebrovascular disease;
Lewy body disease;
Limbic‐predominant age‐related TDP-43 encephalopa
- From:
Chinese Journal of Neuromedicine
2025;24(9):922-927
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the neuropathological characteristics of brain tissues from autopsy of patients with schizophrenia.Methods:Forty-two autopsy cases from National Human Brain Bank for Health and Disease, School of Medicine, Zhejiang University from January 2013 to December 2024 were selected as research subjects, among which, 21 were schizophrenia patients(schizophrenia group) and 21 were non-schizophrenia patients (non-schizophrenia group). Clinical data of patients from the two groups were compared. HE staining was used to detect the pathological changes such as infarction, hemorrhage and arteriosclerosis in the brain tissues, silver-nitrate staining was used to detect the amyloid plaques in the brain tissues, Congo red staining was used to detect the pathological changes related to cerebral amyloid angiopathy (CAA) in the brain tissues, modified Gallyas silver staining was used to detect the neurofibrillary tangles in the brain tissues, and immunohistochemical staining was used to detect the expressions of phosphorylated tau protein, β-amyloid protein (Aβ), TAR DNA binding protein 43 (TDP-43), and α-synuclein in the brain tissues. Alzheimer's disease neuropathologic change (ADNC), primary age-related tauopathy (PART), limbic-predominant age-related TDP-43 encephalopathy (LATE), aging-related tau astrogliopathy (ARTAG), Lewy body disease (LBD), and cerebrovascular disease (CVD)-related pathological changes in the brain tissues were evaluated, and differences in positive rates of the above pathological changes were compared.Results:No significant difference in gender, age of death, brain weight, or apolipoprotein E genotype was noted between the schizophrenia group and non-schizophrenia group ( P>0.05). Six schizophrenia patients exhibited low-to-intermediate ADNC, including 4 with low ADNC and 2 with intermediate ADNC. Compared with the non-schizophrenia group, the positive rates of ADNC- and CVD-related pathological changes in the schizophrenia group were significantly higher (0 vs. 28.6%; 9.5% vs. 47.6%, P<0.05). No significant differences in positive rates of PART-, LATE-, ARTAG-, and LBD-related pathological changes were noted between the schizophrenia group and non-schizophrenia group ( P>0.05). Conclusion:Schizophrenia patients show high proportions of ADNC- and CVD-related pathological changes, but relatively low ADNC severity.
