Recent advance in synergistic role of imaging and molecular pathology in diagnosis and targeted therapy for intracranial melanoma
10.3760/cma.j.cn115354-20241224-00805
- VernacularTitle:影像学与分子病理学在颅内黑色素瘤诊断及靶向治疗中的协同作用研究进展
- Author:
Yuanhao LIU
1
;
Yunqian LI
1
;
Yubo WANG
1
;
Linnan DUAN
1
Author Information
1. 吉林大学第一医院神经肿瘤外科，吉林 130000
- Publication Type:Journal Article
- Keywords:
Intracranial melanoma;
Imaging;
Molecular pathology;
Synergistic role
- From:
Chinese Journal of Neuromedicine
2025;24(5):532-537
- CountryChina
- Language:Chinese
-
Abstract:
The imaging features of intracranial melanoma are similar to those of other intracranial tumors, and a definite diagnosis often cannot be made solely based on imaging examinations. Although molecular pathology can detect gene mutations and protein markers of intracranial melanoma, its diagnostic specificity is limited due to the cross-expression of markers. Studies have shown that the combined application of imaging and molecular pathology can obviously improve the diagnosis sensitivity and specificity of intracranial melanoma, and by integrating the morphological and molecular characteristics of the melanoma, this combined application can optimize individualized treatment strategies and play important roles in surgical planning, targeted therapy selection, and therapeutic efficacy detection. This article reviews the research progress on the synergistic role of imaging and molecular pathology in the diagnosis and targeted therapy of intracranial melanoma, with the aim of providing a reference for diagnosis and treatment of intracranial melanoma.
