Recent advance in role of gut microbiota in pathogenesis and treatment of depression
10.3760/cma.j.cn115354-20250211-00072
- VernacularTitle:肠道菌群在抑郁症发病机制及治疗中的研究进展
- Author:
Lili LI
1
;
Cancan HE
;
Chunming XIE
Author Information
1. 东南大学医学院，南京 210009
- Publication Type:Journal Article
- Keywords:
Major depressive disorder;
Blood-brain barrier;
Gut microbiota;
Microbiota-gut-brain axis
- From:
Chinese Journal of Neuromedicine
2025;24(5):519-523
- CountryChina
- Language:Chinese
-
Abstract:
Major depressive disorder (MDD) is a common mental disorder, whose pathogenesis has not been fully elucidated. Recent studies have shown that gut microbiota can regulate the permeability of blood-brain barrier (BBB) through microbiota-gut-brain axis, thereby affecting the function of brain regions related to emotion and participating in MDD development. This article reviews the recent advance in gut microbiota in the pathogenesis and treatment of MDD, with the aim of providing a reference for clinical treatment of MDD.
